Design, synthesis, and screening of sulfonylurea-derived NLRP3 inflammasome inhibitors

Inflammasomes are multiprotein assemblies that produce robust inflammatory responses upon stimulation with pathogen- and/or danger-associated molecular patterns. Uncontrolled inflammasome activation has been linked to the pathophysiology of a wide array of disorders including life-threatening pathog...

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Bibliographic Details
Published in:Med Chem Res
Main Authors: Kulkarni, Amol A., Sajith, Ayyiliath M., Duarte, Trevor T., Tena, Anahis, Spencer, Charles T., Bowen, J. Phillip
Format: Artigo
Language:Inglês
Published: Springer US 2019
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7223447/
https://ncbi.nlm.nih.gov/pubmed/32435125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00044-019-02466-7
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