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Haplotype-aware graph indexes

MOTIVATION: The variation graph toolkit (VG) represents genetic variation as a graph. Although each path in the graph is a potential haplotype, most paths are non-biological, unlikely recombinations of true haplotypes. RESULTS: We augment the VG model with haplotype information to identify which pat...

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Detalhes bibliográficos
Publicado no:Bioinformatics
Main Authors: Sirén, Jouni, Garrison, Erik, Novak, Adam M, Paten, Benedict, Durbin, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7223266/
https://ncbi.nlm.nih.gov/pubmed/31406990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btz575
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