Computer-Driven Development of an in Silico Tool for Finding Selective Histone Deacetylase 1 Inhibitors

Histone deacetylases (HDACs) are a class of epigenetic modulators overexpressed in numerous types of cancers. Consequently, HDAC inhibitors (HDACIs) have emerged as promising antineoplastic agents. Unfortunately, the most developed HDACIs suffer from poor selectivity towards a specific isoform, limi...

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Veröffentlicht in:Molecules
Hauptverfasser: Sirous, Hajar, Campiani, Giuseppe, Brogi, Simone, Calderone, Vincenzo, Chemi, Giulia
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7221830/
https://ncbi.nlm.nih.gov/pubmed/32331470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25081952
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