Myogenic Progenitor Cell Lineage Specification by CRISPR/Cas9-Based Transcriptional Activators

Engineered CRISPR/Cas9-based transcriptional activators can potently and specifically activate endogenous fate-determining genes to direct differentiation of pluripotent stem cells. Here, we demonstrate that endogenous activation of the PAX7 transcription factor results in stable epigenetic remodeli...

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Publicado en:Stem Cell Reports
Autores principales: Kwon, Jennifer B., Vankara, Ashish, Ettyreddy, Adarsh R., Bohning, Joel D., Gersbach, Charles A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7221109/
https://ncbi.nlm.nih.gov/pubmed/32330446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2020.03.026
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