Generation of novel Il2rg-knockout mice with clustered regularly interspaced short palindromic repeats (CRISPR) and Cas9

X-linked severe combined immunodeficiency (X-SCID) is an inherited genetic disorder. A majority of X-SCID subjects carries point mutations in the Interleukin-2 receptor gamma chain (IL2RG) gene. In contrast, Il2rg-knockout mice recapitulating X-SCID phenotype lack a large part of Il2rg instead of po...

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Bibliographic Details
Published in:Exp Anim
Main Authors: Byambaa, Suvd, Uosaki, Hideki, Hara, Hiromasa, Nagao, Yasumitsu, Abe, Tomoyuki, Shibata, Hiroaki, Nureki, Osamu, Ohmori, Tsukasa, Hanazono, Yutaka
Format: Artigo
Language:Inglês
Published: Japanese Association for Laboratory Animal Science 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7220705/
https://ncbi.nlm.nih.gov/pubmed/31801915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1538/expanim.19-0120
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