Novel insights into breast cancer copy number genetic heterogeneity revealed by single-cell genome sequencing

Copy number alterations (CNAs) play an important role in molding the genomes of breast cancers and have been shown to be clinically useful for prognostic and therapeutic purposes. However, our knowledge of intra-tumoral genetic heterogeneity of this important class of somatic alterations is limited....

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Vydáno v:eLife
Hlavní autoři: Baslan, Timour, Kendall, Jude, Volyanskyy, Konstantin, McNamara, Katherine, Cox, Hilary, D'Italia, Sean, Ambrosio, Frank, Riggs, Michael, Rodgers, Linda, Leotta, Anthony, Song, Junyan, Mao, Yong, Wu, Jie, Shah, Ronak, Gularte-Mérida, Rodrigo, Chadalavada, Kalyani, Nanjangud, Gouri, Varadan, Vinay, Gordon, Assaf, Curtis, Christina, Krasnitz, Alex, Dimitrova, Nevenka, Harris, Lyndsay, Wigler, Michael, Hicks, James
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2020
Témata:
Cancer Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7220379/
https://ncbi.nlm.nih.gov/pubmed/32401198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51480
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