ZBTB1 Regulates Asparagine Synthesis and Leukemia Cell Response to L-Asparaginase

Activating transcription factor 4 (ATF4) is a master transcriptional regulator of the integrated stress response (ISR) that enables cell survival under nutrient stress. The mechanisms by which ATF4 couples metabolic stresses to specific transcriptional outputs remain unknown. Using functional genomi...

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Veröffentlicht in:Cell Metab
Hauptverfasser: Williams, Robert T., Guarecuco, Rohiverth, Gates, Leah A., Barrows, Douglas, Passarelli, Maria C., Carey, Bryce, Baudrier, Lou, Jeewajee, Swarna, La, Konnor, Prizer, Benjamin, Malik, Sohail, Garcia-Bermudez, Javier, Zhu, Xiphias Ge, Cantor, Jason, Molina, Henrik, Carroll, Thomas, Roeder, Robert G., Abdel-Wahab, Omar, Allis, C. David, Birsoy, Kıvanç
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7219601/
https://ncbi.nlm.nih.gov/pubmed/32268116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2020.03.008
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