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Catalytic Ring Expansions of Cyclic Alcohols Enabled by Proton-Coupled Electron Transfer

We report here a catalytic method for the modular ring expansion of cyclic aliphatic alcohols. In this work, proton-coupled electron transfer (PCET) activation of an allylic alcohol substrate affords an alkoxy radical intermediate that undergoes subsequent C–C bond cleavage to furnish an enone and a...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Zhao, Kuo, Yamashita, Kenji, Carpenter, Joseph E., Sherwood, Trevor C., Ewing, William R., Cheng, Peter T. W., Knowles, Robert R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7219538/
https://ncbi.nlm.nih.gov/pubmed/31117664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b03973
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