Inhibition of K(Ca)2 and K(v)11.1 Channels in Pigs With Left Ventricular Dysfunction

BACKGROUND: Inhibition of K(Ca)2 channels, conducting I(KCa), can convert atrial fibrillation (AF) to sinus rhythm and protect against its induction. I(KCa) inhibition has been shown to possess functional atrial selectivity with minor effects on ventricles. Under pathophysiological conditions with v...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Citerni, Carlotta, Kirchhoff, Jeppe, Olsen, Lisbeth Høier, Sattler, Stefan Michael, Grunnet, Morten, Edvardsson, Nils, Bentzen, Bo Hjorth, Diness, Jonas Goldin
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7219273/
https://ncbi.nlm.nih.gov/pubmed/32435191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00556
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