Inhibition of K(Ca)2 Channels Decreased the Risk of Ventricular Arrhythmia in the Guinea Pig Heart During Induced Hypokalemia

BACKGROUND: Hypokalemia reduces the cardiac repolarization reserve. This prolongs the QT-interval and increases the risk of ventricular arrhythmia; a risk that is exacerbated by administration of classical class 3 anti-arrhythmic agents. Small conductance Ca(2+)-activated K(+)-channels (K(Ca)2) are...

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Bibliografski detalji
Izdano u:Front Pharmacol
Glavni autori: Diness, Jonas Goldin, Abildgaard, Lea, Bomholtz, Sofia Hammami, Skarsfeldt, Mark Alexander, Edvardsson, Nils, Sørensen, Ulrik S., Grunnet, Morten, Bentzen, Bo Hjorth
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2020
Teme:
Pharmacology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7251152/
https://ncbi.nlm.nih.gov/pubmed/32508659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00749
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