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Mec1(ATR) autophosphorylation and Ddc2(ATRIP) phosphorylation regulates DNA damage checkpoint signaling
In budding yeast, a single DNA double-strand break (DSB) triggers the activation of Mec1(ATR)-dependent DNA damage checkpoint. After about 12h, cells turn off the checkpoint signaling and adapt despite persistence of the DSB. We report that adaptation involves the autophosphorylation of Mec1 at site...
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| Izdano u: | Cell Rep |
|---|---|
| Glavni autori: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2019
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7218798/ https://ncbi.nlm.nih.gov/pubmed/31340146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.06.068 |
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