Tissue-specific effects of an anti-desmoglein-3 ADCC antibody due to expression of the target antigen and physiological characteristics of the mouse vagina

Desmoglein-3 (DSG3) is a potential target of cytotoxic antibody therapy for squamous cell carcinomas but is also expressed in various normal squamous epithelia. We obtained information about DSG3 distribution in mouse tissues by immunohistochemistry and conducted an intravenous multiple-dose study i...

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Vydáno v:J Toxicol Pathol
Hlavní autoři: Fujii, Etsuko, Funahashi, Shinichi, Taniguchi, Kenji, Kawai, Shigeto, Nakano, Kiyotaka, Kato, Atsuhiko, Suzuki, Masami
Médium: Artigo
Jazyk:Inglês
Vydáno: Japanese Society of Toxicologic Pathology 2019
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7218237/
https://ncbi.nlm.nih.gov/pubmed/32425339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1293/tox.2019-0040
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