Tissue-specific effects of an anti-desmoglein-3 ADCC antibody due to expression of the target antigen and physiological characteristics of the mouse vagina

Desmoglein-3 (DSG3) is a potential target of cytotoxic antibody therapy for squamous cell carcinomas but is also expressed in various normal squamous epithelia. We obtained information about DSG3 distribution in mouse tissues by immunohistochemistry and conducted an intravenous multiple-dose study i...

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Detalhes bibliográficos
Publicado no:J Toxicol Pathol
Main Authors: Fujii, Etsuko, Funahashi, Shinichi, Taniguchi, Kenji, Kawai, Shigeto, Nakano, Kiyotaka, Kato, Atsuhiko, Suzuki, Masami
Formato: Artigo
Idioma:Inglês
Publicado em: Japanese Society of Toxicologic Pathology 2019
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7218237/
https://ncbi.nlm.nih.gov/pubmed/32425339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1293/tox.2019-0040
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