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Three-dimensional culture models mimic colon cancer heterogeneity induced by different microenvironments

Colorectal cancer demonstrates intra-tumour heterogeneity formed by a hierarchical structure comprised of cancer stem cells (CSCs) and their differentiated progenies. The mechanism by which CSCs are maintained and differentiated needs to be further elucidated, and there is evidence that the tumour m...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Kawai, Shigeto, Yamazaki, Masaki, Shibuya, Keita, Yamazaki, Masaya, Fujii, Etsuko, Nakano, Kiyotaka, Suzuki, Masami
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7035265/
https://ncbi.nlm.nih.gov/pubmed/32081957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-60145-9
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