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Three-dimensional culture models mimic colon cancer heterogeneity induced by different microenvironments

Colorectal cancer demonstrates intra-tumour heterogeneity formed by a hierarchical structure comprised of cancer stem cells (CSCs) and their differentiated progenies. The mechanism by which CSCs are maintained and differentiated needs to be further elucidated, and there is evidence that the tumour m...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kawai, Shigeto, Yamazaki, Masaki, Shibuya, Keita, Yamazaki, Masaya, Fujii, Etsuko, Nakano, Kiyotaka, Suzuki, Masami
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7035265/
https://ncbi.nlm.nih.gov/pubmed/32081957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-60145-9
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