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Branched photoswitchable tethered ligands enable ultra-efficient optical control and detection of G protein-coupled receptors in vivo
The limitations of classical drugs have spurred the development of covalently-tethered photoswitchable ligands to control neuromodulatory receptors. However, a major shortcoming of tethered photopharmacology is the inability to obtain optical control with a comparable efficacy to the native ligand....
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| Pubblicato in: | Neuron |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7216301/ https://ncbi.nlm.nih.gov/pubmed/31784287 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2019.10.036 |
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