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SNAP-Tagged Nanobodies Enable Reversible Optical Control of a G Protein-Coupled Receptor via a Remotely Tethered Photoswitchable Ligand

G protein-coupled receptors (GPCRs) mediate the transduction of extracellular signals into complex intracellular responses. Despite their ubiquitous roles in physiological processes and as drug targets for a wide range of disorders, the precise mechanisms of GPCR function at the molecular, cellular,...

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Bibliografiska uppgifter
I publikationen:ACS Chem Biol
Huvudupphovsmän: Farrants, Helen, Gutzeit, Vanessa A., Acosta-Ruiz, Amanda, Trauner, Dirk, Johnsson, Kai, Levitz, Joshua, Broichhagen, Johannes
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6620112/
https://ncbi.nlm.nih.gov/pubmed/30141622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00628
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