Improved GPCR ligands from nanobody tethering

Antibodies conjugated to bioactive compounds allow targeted delivery of therapeutics to cell types of choice based on that antibody’s specificity. Here we develop a new type of conjugate that consists of a nanobody and a peptidic ligand for a G protein-coupled receptor (GPCR), fused via their C-term...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Cheloha, Ross W., Fischer, Fabian A., Woodham, Andrew W., Daley, Eileen, Suminski, Naomi, Gardella, Thomas J., Ploegh, Hidde L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190724/
https://ncbi.nlm.nih.gov/pubmed/32350260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15884-8
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak