Improved GPCR ligands from nanobody tethering

Antibodies conjugated to bioactive compounds allow targeted delivery of therapeutics to cell types of choice based on that antibody’s specificity. Here we develop a new type of conjugate that consists of a nanobody and a peptidic ligand for a G protein-coupled receptor (GPCR), fused via their C-term...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Nat Commun
Autori principali: Cheloha, Ross W., Fischer, Fabian A., Woodham, Andrew W., Daley, Eileen, Suminski, Naomi, Gardella, Thomas J., Ploegh, Hidde L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190724/
https://ncbi.nlm.nih.gov/pubmed/32350260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15884-8
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi