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A nanobody that recognizes a 14-residue peptide epitope in the E2 ubiquitin-conjugating enzyme UBC6e modulates its activity.

A substantial fraction of eukaryotic proteins is folded and modified in the endoplasmic reticulum (ER) prior to export and secretion. Proteins that enter the ER but fail to fold correctly must be degraded, mostly in a process termed ER-associated degradation (ERAD). Both protein folding in the ER an...

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Bibliografske podrobnosti
izdano v:Mol Immunol
Main Authors: Ling, Jingjing, Cheloha, Ross W., McCaul, Nicholas, Sun, Zhen-Yu J., Wagner, Gerhard, Ploegh, Hidde L.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774866/
https://ncbi.nlm.nih.gov/pubmed/31518855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2019.08.008
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