Cryo-EM Structures of Human Drosha and DGCR8 in Complex with Primary MicroRNA

Metazoan microRNAs require specific maturation steps initiated by Microprocessor, comprised of Drosha and DGCR8. Lack of structural information for the assembled complex has hindered understanding how Microprocessor recognizes primary microRNA transcripts (pri-miRNAs). Here we present a cryo-electro...

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Bibliographic Details
Published in:Mol Cell
Main Authors: Partin, Alexander C., Zhang, Kaiming, Jeong, Byung-Cheon, Herrell, Emily, Li, Shanshan, Chiu, Wah, Nam, Yunsun
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7214211/
https://ncbi.nlm.nih.gov/pubmed/32220646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.02.016
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