Mosaic mutant analysis identifies PDGFRα/PDGFRβ as negative regulators of adipogenesis

Adipocyte progenitors (APs) express platelet-derived growth factor receptors, PDGFRα and PDGFRβ. Elevated PDGFRα signaling inhibits adipogenesis and promotes fibrosis, however the function of PDGFRs in APs remains unclear. We combined lineage tracing and functional analyses in a sequential dual-reco...

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Publicat a:Cell Stem Cell
Autors principals: Sun, Chengyi, Sakashita, Hiromi, Kim, Jang, Tang, Zifeng, Upchurch, G. Michael, Yao, Longbiao, Berry, William L., Griffin, Timothy M., Olson, Lorin E.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7214206/
https://ncbi.nlm.nih.gov/pubmed/32229310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2020.03.004
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