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Increased PDGFRα Activation Disrupts Connective Tissue Development and Drives Systemic Fibrosis
PDGF signaling regulates the development of mesenchymal cell types in the embryo and in the adult, but the role of receptor activation in tissue homeostasis has not been investigated. We have generated conditional knockin mice with mutations in PDGFRα that drive increased kinase activity under the c...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2664622/ https://ncbi.nlm.nih.gov/pubmed/19217431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2008.12.003 |
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