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Estimating the power of sequence covariation for detecting conserved RNA structure

Pairwise sequence covariations are a signal of conserved RNA secondary structure. We describe a method for distinguishing when lack of covariation signal can be taken as evidence against a conserved RNA structure, as opposed to when a sequence alignment merely has insufficient variation to detect co...

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Bibliografski detalji
Izdano u:Bioinformatics
Glavni autori: Rivas, Elena, Clements, Jody, Eddy, Sean R
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7214042/
https://ncbi.nlm.nih.gov/pubmed/32031582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btaa080
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