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Coolpup.py: versatile pile-up analysis of Hi-C data

MOTIVATION: Hi-C is currently the method of choice to investigate the global 3D organization of the genome. A major limitation of Hi-C is the sequencing depth required to robustly detect loops in the data. A popular approach used to mitigate this issue, even in single-cell Hi-C data, is genome-wide...

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Publicat a:Bioinformatics
Autors principals: Flyamer, Ilya M, Illingworth, Robert S, Bickmore, Wendy A
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7214034/
https://ncbi.nlm.nih.gov/pubmed/32003791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btaa073
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