Intestinal alkaline phosphatase targets the gut barrier to prevent aging

Gut barrier dysfunction and gut-derived chronic inflammation play crucial roles in human aging. The gut brush border enzyme intestinal alkaline phosphatase (IAP) functions to inhibit inflammatory mediators and also appears to be an important positive regulator of gut barrier function and microbial h...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Kühn, Florian, Adiliaghdam, Fatemeh, Cavallaro, Paul M., Hamarneh, Sulaiman R., Tsurumi, Amy, Hoda, Raza S., Munoz, Alexander R., Dhole, Yashoda, Ramirez, Juan M., Liu, Enyu, Vasan, Robin, Liu, Yang, Samarbafzadeh, Ehsan, Nunez, Rocio A., Farber, Matthew Z., Chopra, Vanita, Malo, Madhu S., Rahme, Laurence G., Hodin, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213802/
https://ncbi.nlm.nih.gov/pubmed/32213701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.134049
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