Intestinal alkaline phosphatase inhibits the proinflammatory nucleotide uridine diphosphate

Uridine diphosphate (UDP) is a proinflammatory nucleotide implicated in inflammatory bowel disease. Intestinal alkaline phosphatase (IAP) is a gut mucosal defense factor capable of inhibiting intestinal inflammation. We used the malachite green assay to show that IAP dephosphorylates UDP. To study t...

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Detalhes bibliográficos
Main Authors: Moss, Angela K., Hamarneh, Sulaiman R., Mohamed, Mussa M. Rafat, Ramasamy, Sundaram, Yammine, Halim, Patel, Palak, Kaliannan, Kanakaraju, Alam, Sayeda N., Muhammad, Nur, Moaven, Omeed, Teshager, Abeba, Malo, Nondita S., Narisawa, Sonoko, Millán, José Luis, Warren, H. Shaw, Hohmann, Elizabeth, Malo, Madhu S., Hodin, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
Assuntos:
Inflammation/Immunity/Mediators
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602687/
https://ncbi.nlm.nih.gov/pubmed/23306083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00455.2012
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