Osteoclast-derived IGF1 is required for pagetic lesion formation in vivo

We report that transgenic mice expressing measles virus nucleocapsid protein (MVNP) in osteoclasts (OCLs) (MVNP mice) are Paget’s disease (PD) models and that OCLs from patients with PD and MVNP mice express high levels of OCL-derived IGF1 (OCL-IGF1). To determine OCL-IGF1’s role in PD and normal bo...

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Détails bibliographiques
Publié dans:JCI Insight
Auteurs principaux: Miyagawa, Kazuaki, Ohata, Yasuhisa, Delgado-Calle, Jesus, Teramachi, Jumpei, Zhou, Hua, Dempster, David D., Subler, Mark A., Windle, Jolene J., Chirgwin, John M., Roodman, G. David, Kurihara, Noriyoshi
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2020
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213785/
https://ncbi.nlm.nih.gov/pubmed/32078587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.133113
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