Osteoclast-derived IGF1 is required for pagetic lesion formation in vivo

We report that transgenic mice expressing measles virus nucleocapsid protein (MVNP) in osteoclasts (OCLs) (MVNP mice) are Paget’s disease (PD) models and that OCLs from patients with PD and MVNP mice express high levels of OCL-derived IGF1 (OCL-IGF1). To determine OCL-IGF1’s role in PD and normal bo...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Miyagawa, Kazuaki, Ohata, Yasuhisa, Delgado-Calle, Jesus, Teramachi, Jumpei, Zhou, Hua, Dempster, David D., Subler, Mark A., Windle, Jolene J., Chirgwin, John M., Roodman, G. David, Kurihara, Noriyoshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213785/
https://ncbi.nlm.nih.gov/pubmed/32078587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.133113
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