Increased IL-6 Expression in Osteoclasts Is Necessary But Not Sufficient for the Development of Paget’s Disease of Bone

Measles virus nucleocapsid protein (MVNP) expression in osteoclasts (OCLs) and mutation of the SQSTM1 (p62) gene contribute to the increased OCL activity in Paget’s disease (PD). OCLs expressing MVNP display many of the features of PD OCLs. Interleukin-6 (IL-6) production is essential for the pageti...

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Vydáno v:J Bone Miner Res
Hlavní autoři: Teramachi, Jumpei, Zhou, Hua, Subler, Mark A, Kitagawa, Yukiko, Galson, Deborah L, Dempster, David W, Windle, Jolene J, Kurihara, Noriyoshi, Roodman, G David
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4361000/
https://ncbi.nlm.nih.gov/pubmed/24339057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2158
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