Increased IL-6 Expression in Osteoclasts Is Necessary But Not Sufficient for the Development of Paget’s Disease of Bone

Measles virus nucleocapsid protein (MVNP) expression in osteoclasts (OCLs) and mutation of the SQSTM1 (p62) gene contribute to the increased OCL activity in Paget’s disease (PD). OCLs expressing MVNP display many of the features of PD OCLs. Interleukin-6 (IL-6) production is essential for the pageti...

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發表在:J Bone Miner Res
Main Authors: Teramachi, Jumpei, Zhou, Hua, Subler, Mark A, Kitagawa, Yukiko, Galson, Deborah L, Dempster, David W, Windle, Jolene J, Kurihara, Noriyoshi, Roodman, G David
格式: Artigo
語言:Inglês
出版: 2014
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4361000/
https://ncbi.nlm.nih.gov/pubmed/24339057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2158
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