TB-06 MOLECULAR MECHANISM OF BRAIN TUMOUR FORMATION DRIVEN BY SUPRATENTORIAL EPENDYMOMA-SPECIFIC YAP1 FUSION GENES

YAP1 fusion-positive supratentorial ependymomas predominantly occur in infants, but the molecular mechanisms of oncogenesis are unknown. Here we show YAP1-MAMLD1 fusions but not YAP1 wildtype are sufficient to drive malignant transformation of neural progenitors in the developing cerebral cortex in...

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Publicado en:Neurooncol Adv
Main Authors: Kawauchi, Daisuke, Pajtler, Kristian, Wei, Yiju, Okonechnikov, Konstantin, Silva, Patricia, Jones, David, Hoshino, Mikio, Pfister, Stefan, Kool, Marcel, Li, Wei
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213335/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdz039.048
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