Effects of valproic acid on histone deacetylase inhibition in vitro and in glioblastoma patient samples

BACKGROUND: The antiepileptic drug valproic acid (VPA) inhibits histone deacetylase in glioblastoma cells in vitro, which influences several oncogenic pathways and decreases glioma cell proliferation. The clinical relevance of these observations remains unclear, as VPA does not seem to affect gliobl...

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Vydáno v:Neurooncol Adv
Hlavní autoři: Berendsen, Sharon, Frijlink, Elselien, Kroonen, Jèrôme, Spliet, Wim G M, van Hecke, Wim, Seute, Tatjana, Snijders, Tom J, Robe, Pierre A
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Basic and Translational Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7212905/
https://ncbi.nlm.nih.gov/pubmed/32642660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdz025
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