Effects of valproic acid on histone deacetylase inhibition in vitro and in glioblastoma patient samples

BACKGROUND: The antiepileptic drug valproic acid (VPA) inhibits histone deacetylase in glioblastoma cells in vitro, which influences several oncogenic pathways and decreases glioma cell proliferation. The clinical relevance of these observations remains unclear, as VPA does not seem to affect gliobl...

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Detalhes bibliográficos
Publicado no:Neurooncol Adv
Main Authors: Berendsen, Sharon, Frijlink, Elselien, Kroonen, Jèrôme, Spliet, Wim G M, van Hecke, Wim, Seute, Tatjana, Snijders, Tom J, Robe, Pierre A
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7212905/
https://ncbi.nlm.nih.gov/pubmed/32642660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdz025
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