Effects of valproic acid on histone deacetylase inhibition in vitro and in glioblastoma patient samples

BACKGROUND: The antiepileptic drug valproic acid (VPA) inhibits histone deacetylase in glioblastoma cells in vitro, which influences several oncogenic pathways and decreases glioma cell proliferation. The clinical relevance of these observations remains unclear, as VPA does not seem to affect gliobl...

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Publicat a:Neurooncol Adv
Autors principals: Berendsen, Sharon, Frijlink, Elselien, Kroonen, Jèrôme, Spliet, Wim G M, van Hecke, Wim, Seute, Tatjana, Snijders, Tom J, Robe, Pierre A
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Basic and Translational Investigations
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7212905/
https://ncbi.nlm.nih.gov/pubmed/32642660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdz025
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