Effects of valproic acid on histone deacetylase inhibition in vitro and in glioblastoma patient samples

BACKGROUND: The antiepileptic drug valproic acid (VPA) inhibits histone deacetylase in glioblastoma cells in vitro, which influences several oncogenic pathways and decreases glioma cell proliferation. The clinical relevance of these observations remains unclear, as VPA does not seem to affect gliobl...

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Detaylı Bibliyografya
Yayımlandı:Neurooncol Adv
Asıl Yazarlar: Berendsen, Sharon, Frijlink, Elselien, Kroonen, Jèrôme, Spliet, Wim G M, van Hecke, Wim, Seute, Tatjana, Snijders, Tom J, Robe, Pierre A
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2019
Konular:
Basic and Translational Investigations
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7212905/
https://ncbi.nlm.nih.gov/pubmed/32642660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdz025
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