Effects of valproic acid on histone deacetylase inhibition in vitro and in glioblastoma patient samples

BACKGROUND: The antiepileptic drug valproic acid (VPA) inhibits histone deacetylase in glioblastoma cells in vitro, which influences several oncogenic pathways and decreases glioma cell proliferation. The clinical relevance of these observations remains unclear, as VPA does not seem to affect gliobl...

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Bibliografiske detaljer
Udgivet i:Neurooncol Adv
Main Authors: Berendsen, Sharon, Frijlink, Elselien, Kroonen, Jèrôme, Spliet, Wim G M, van Hecke, Wim, Seute, Tatjana, Snijders, Tom J, Robe, Pierre A
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Basic and Translational Investigations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7212905/
https://ncbi.nlm.nih.gov/pubmed/32642660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdz025
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