ULK1 inhibition as a targeted therapeutic strategy for FLT3-ITD-mutated acute myeloid leukemia

BACKGROUND: In acute myeloid leukemia (AML), internal tandem duplication mutations in the FLT3 tyrosine kinase receptor (FLT3-ITD) are associated with a dismal outcome. Although uncoordinated 51-like kinase 1 (ULK1), which plays a central role in the autophagy pathway, has emerged as a novel therape...

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Publicat a:J Exp Clin Cancer Res
Autors principals: Hwang, Doh Yu, Eom, Ju-In, Jang, Ji Eun, Jeung, Hoi-Kyung, Chung, Haerim, Kim, Jin Seok, Cheong, June-Won, Min, Yoo Hong
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7212592/
https://ncbi.nlm.nih.gov/pubmed/32393312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-020-01580-4
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