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PERK/NRF2 and autophagy form a resistance mechanism against G9a inhibition in leukemia stem cells
BACKGROUND: The histone methyltransferase G9a has recently been identified as a potential target for epigenetic therapy of acute myeloid leukemia (AML). However, the effect of G9a inhibition on leukemia stem cells (LSCs), which are responsible for AML drug resistance and recurrence, is unclear. In t...
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| Publicado no: | J Exp Clin Cancer Res |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7158163/ https://ncbi.nlm.nih.gov/pubmed/32293500 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-020-01565-3 |
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