PERK/NRF2 and autophagy form a resistance mechanism against G9a inhibition in leukemia stem cells

BACKGROUND: The histone methyltransferase G9a has recently been identified as a potential target for epigenetic therapy of acute myeloid leukemia (AML). However, the effect of G9a inhibition on leukemia stem cells (LSCs), which are responsible for AML drug resistance and recurrence, is unclear. In t...

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Publicado en:J Exp Clin Cancer Res
Autores principales: Jang, Ji Eun, Eom, Ju-In, Jeung, Hoi-Kyung, Chung, Haerim, Kim, Yu Ri, Kim, Jin Seok, Cheong, June-Won, Min, Yoo Hong
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2020
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Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7158163/
https://ncbi.nlm.nih.gov/pubmed/32293500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-020-01565-3
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