Arsenic trioxide synergistically promotes the antileukaemic activity of venetoclax by downregulating Mcl-1 in acute myeloid leukaemia cells

BACKGROUND: The evasion of apoptosis through dysregulated Bcl-2 family members is a hallmark of leukaemia stem cells (LSCs) in acute myeloid leukaemia (AML). Therefore, targeting Bcl-2 with venetoclax has been suggested as an attractive strategy for inducing apoptosis in AML LSCs. However, the selec...

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Detalhes bibliográficos
Publicado no:Exp Hematol Oncol
Main Authors: Cho, Hyunsoo, Jang, Ji Eun, Eom, Ju-In, Jeung, Hoi-Kyung, Chung, Haerim, Kim, Jin Seok, Cheong, June-Won, Min, Yoo Hong
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8051086/
https://ncbi.nlm.nih.gov/pubmed/33858507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40164-021-00221-6
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