PERK/NRF2 and autophagy form a resistance mechanism against G9a inhibition in leukemia stem cells

BACKGROUND: The histone methyltransferase G9a has recently been identified as a potential target for epigenetic therapy of acute myeloid leukemia (AML). However, the effect of G9a inhibition on leukemia stem cells (LSCs), which are responsible for AML drug resistance and recurrence, is unclear. In t...

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Publicat a:J Exp Clin Cancer Res
Autors principals: Jang, Ji Eun, Eom, Ju-In, Jeung, Hoi-Kyung, Chung, Haerim, Kim, Yu Ri, Kim, Jin Seok, Cheong, June-Won, Min, Yoo Hong
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7158163/
https://ncbi.nlm.nih.gov/pubmed/32293500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-020-01565-3
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