Aurora A kinase expression is increased in leukemia stem cells, and a selective Aurora A kinase inhibitor enhances Ara-C-induced apoptosis in acute myeloid leukemia stem cells

BACKGROUND: The overexpression of Aurora A kinase (AurA) has been reported in various malignancies, including acute myeloid leukemia (AML). However, the expression of AurA and the effects of AurA inhibition in cancer stem cells are not yet fully understood. We investigated the expression and inhibit...

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Bibliografiske detaljer
Main Authors: Kim, Soo-Jeong, Jang, Ji Eun, Cheong, June-Won, Eom, Ju-In, Jeung, Hoi-Kyung, Kim, Yundeok, Hwang, Doh Yu, Min, Yoo Hong
Format: Artigo
Sprog:Inglês
Udgivet: Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis 2012
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464334/
https://ncbi.nlm.nih.gov/pubmed/23071472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5045/kjh.2012.47.3.178
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