Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases

Obesity is associated with changes in the secretome of adipose tissue (AT), which affects the vasculature through endocrine and paracrine mechanisms. Wingless-related integration site 5A (WNT5A) and secreted frizzled related protein 5 (SFRP5), adipokines that regulate non-canonical Wnt signaling, ar...

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Bibliografski detalji
Izdano u:Sci Transl Med
Glavni autori: Akoumianakis, Ioannis, Sanna, Fabio, Margaritis, Marios, Badi, Ileana, Akawi, Nadia, Herdman, Laura, Coutinho, Patricia, Fagan, Harry, Antonopoulos, Alexios S, Oikonomou, Evangelos K, Thomas, Sheena, Chiu, Amy P, Chuaiphichai, Surawee, Kotanidis, Christos P, Christodoulides, Constantinos, Petrou, Mario, Krasopoulos, George, Sayeed, Rana, Lv, Lei, Hale, Ashley, Kararoudi, Meisam Naeimi, McNeill, Eileen, Douglas, Gillian, George, Sarah, Tousoulis, Dimitris, Channon, Keith M, Antoniades, Charalambos
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7212031/
https://ncbi.nlm.nih.gov/pubmed/31534019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aav5055
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