Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases

Obesity is associated with changes in the secretome of adipose tissue (AT), which affects the vasculature through endocrine and paracrine mechanisms. Wingless-related integration site 5A (WNT5A) and secreted frizzled related protein 5 (SFRP5), adipokines that regulate non-canonical Wnt signaling, ar...

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Publicado en:Sci Transl Med
Autores principales: Akoumianakis, Ioannis, Sanna, Fabio, Margaritis, Marios, Badi, Ileana, Akawi, Nadia, Herdman, Laura, Coutinho, Patricia, Fagan, Harry, Antonopoulos, Alexios S, Oikonomou, Evangelos K, Thomas, Sheena, Chiu, Amy P, Chuaiphichai, Surawee, Kotanidis, Christos P, Christodoulides, Constantinos, Petrou, Mario, Krasopoulos, George, Sayeed, Rana, Lv, Lei, Hale, Ashley, Kararoudi, Meisam Naeimi, McNeill, Eileen, Douglas, Gillian, George, Sarah, Tousoulis, Dimitris, Channon, Keith M, Antoniades, Charalambos
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7212031/
https://ncbi.nlm.nih.gov/pubmed/31534019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aav5055
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