Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases

Obesity is associated with changes in the secretome of adipose tissue (AT), which affects the vasculature through endocrine and paracrine mechanisms. Wingless-related integration site 5A (WNT5A) and secreted frizzled related protein 5 (SFRP5), adipokines that regulate non-canonical Wnt signaling, ar...

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Publicado no:Sci Transl Med
Main Authors: Akoumianakis, Ioannis, Sanna, Fabio, Margaritis, Marios, Badi, Ileana, Akawi, Nadia, Herdman, Laura, Coutinho, Patricia, Fagan, Harry, Antonopoulos, Alexios S, Oikonomou, Evangelos K, Thomas, Sheena, Chiu, Amy P, Chuaiphichai, Surawee, Kotanidis, Christos P, Christodoulides, Constantinos, Petrou, Mario, Krasopoulos, George, Sayeed, Rana, Lv, Lei, Hale, Ashley, Kararoudi, Meisam Naeimi, McNeill, Eileen, Douglas, Gillian, George, Sarah, Tousoulis, Dimitris, Channon, Keith M, Antoniades, Charalambos
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7212031/
https://ncbi.nlm.nih.gov/pubmed/31534019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aav5055
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