β2-adrenergic agonists rescue lysosome acidification and function in PSEN1 deficiency by reversing defective ER to lysosome delivery of ClC-7

Lysosomal dysfunction is considered pathogenic in Alzheimer Disease (AD). Loss of Presenilin-1 (PSEN1) function causing AD impedes acidification via defective vATPase V0a1 subunit delivery to lysosomes. We report that isoproterenol and related β2-adrenergic agonists re-acidify lysosomes in PSEN1 KO...

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Publicat a:J Mol Biol
Autors principals: Lee, Ju-Hyun, Wolfe, Devin M., Darji, Sandipkumar, McBrayer, Mary Kate, Colacurcio, Daniel J., Kumar, Asok, Stavrides, Philip, Mohan, Panaiyur S., Nixon, Ralph A.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7211125/
https://ncbi.nlm.nih.gov/pubmed/32105735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2020.02.021
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