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Skin Delivery of siRNA Using Sponge Spicules in Combination with Cationic Flexible Liposomes

We report the topical administration of sponge Haliclona sp. Spicules (SHS) combined with cationic flexible liposomes (CFL) to increase the delivery of small interfering RNA (siRNA) into viable skin cells in vitro and in vivo. SHS can be applied topically as novel microneedles to overcome skin barri...

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Bibliografske podrobnosti
izdano v:Mol Ther Nucleic Acids
Main Authors: Liang, XueJiao, Zhang, JiaLiang, Ou, HuiLong, Chen, Jun, Mitragotri, Samir, Chen, Ming
Format: Artigo
Jezik:Inglês
Izdano: American Society of Gene & Cell Therapy 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7210381/
https://ncbi.nlm.nih.gov/pubmed/32380414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.04.003
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