SUN-665 Peripheral CB(1)R Blocker Improves Metabolism in Diet Induced Obese Mice Independent of Hepatic FGF21

Obesity is associated with an overactive endocannabinoid system, and selective blockade of CB(1)R in peripheral tissues, including the liver, reverses HFD-induced metabolic abnormalities by restoring normal lipid and glucose homeostasis. Fibroblast growth factor-21 (FGF21) has emerged as a major end...

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Bibliografiske detaljer
Udgivet i:J Endocr Soc
Main Authors: Liu, Jie, Godlewski, Grzegorz, Liu, Ziyi, Cinar, Resat, Xiong, Keming, Kunos, George
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Diabetes Mellitus and Glucose Metabolism
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7209388/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.648
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