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Hepatic CB(1) Receptors Mediate Diet-Induced Insulin Resistance by Increasing de novo Synthesis of Long Chain Ceramides
Obesity is associated with increased activity of two lipid signaling systems - endocannabinoids (ECs) and ceramides – with both being implicated in insulin resistance. Cannabinoid-1 receptor (CB(1)R) antagonists reverse obesity and insulin resistance, but have psychiatric side effects. Here we analy...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3839256/ https://ncbi.nlm.nih.gov/pubmed/23832510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26606 |
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