OR01-01 Human Type 1 Iodothyronine Deiodinase (DIO1) Mutations Cause Abnormal Thyroid Hormone Metabolism

Iodothyronine deiodinases (Ds) mediate thyroid hormone (TH) action. They catalyze triiodothyronine (T(3)) production and degradation via, respectively; outer (ORD) and inner (IRD) ring deiodination. Type 1 D (D1) has a relatively high Km for substrates thyroxine (T(4)) and reverse T(3) (rT(3)), cata...

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Publicado en:J Endocr Soc
Autores principales: França, Monica Malheiros, Liao, Xiao Hui, Fernandes, Gustavo Werpel, German, Alina, Bianco, Antonio C, Refetoff, Samuel, Dumitrescu, Alexandra
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
Materias:
Thyroid
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7209097/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.966
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