OR03-06 NAD+ Availability Modulates 11β-HSD1-Mediated Glucocorticoid Regeneration in Mouse Skeletal Muscle

11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is an NADPH-dependant reductase located in the sarcoplasmic reticulum (SR) lumen of skeletal muscle. It generates active glucocorticoids to regulate permissive and adaptive metabolism and contributes to the development of the Cushing’s syndrome phen...

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Publicat a:J Endocr Soc
Autors principals: Elhassan, Yasir S, Kabli, Ali, Nielsen, Thomas, Fletcher, Rachel, Oakey, Lucy, Cartwright, David, Chubanava, Sabina, Garten, Antje, Doig, Craig, Treebak, Jonas Thue, Lavery, Gareth Geoffrey
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
Adrenal
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7208827/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.1657
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