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SAT-299 Chronic Treatment Of Juvenile Hypothalamic Pomc-deficient Mice With RM-493 Prevents The Development Of Obesity

Arc-Pomc knockout mice have a disruption of the two neural enhancers for the Pomc (proopiomelanocortin) gene, resulting in selective loss of Pomc gene expression in the arcuate nucleus of the hypothalamus. This gene targeting strategy leaves pituitary Pomc expression unaffected. These mice are hyper...

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Detalhes bibliográficos
Publicado no:J Endocr Soc
Main Authors: Thompson, Zoe, Shah, Bhavik P, Low, Malcolm J
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7208318/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.330
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