OR31-05 Emergence of Ovarian Hyperandrogenism and Luteal Insufficiency Following ESR1 Knockdown in the Mediobasal Hypothalamus of Adult Female Rhesus Monkeys

Diminished estradiol (E2) negative feedback action by neuronal ESR1 in the arcuate nucleus (ARC) of the mediobasal hypothalamus (MBH) is hypothesized to cause gonadotropin-releasing hormone (GnRH) hypersecretion, and thus LH excess, contributing to ovarian hyperandrogenism in polycystic ovary syndro...

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Dettagli Bibliografici
Pubblicato in:J Endocr Soc
Autori principali: Levine, Jon E, Greinwald, Emily P, Felton, Jesi A, Flowers, Matthew T, Willging, Molly M, Shapiro, Robert A, Keen, Kim L, Terasawa, Ei, Uhlrich, Daniel J, Abbott, David Howard
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
Soggetti:
Reproductive Endocrinology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7207541/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.1320
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