OR31-05 Emergence of Ovarian Hyperandrogenism and Luteal Insufficiency Following ESR1 Knockdown in the Mediobasal Hypothalamus of Adult Female Rhesus Monkeys

Diminished estradiol (E2) negative feedback action by neuronal ESR1 in the arcuate nucleus (ARC) of the mediobasal hypothalamus (MBH) is hypothesized to cause gonadotropin-releasing hormone (GnRH) hypersecretion, and thus LH excess, contributing to ovarian hyperandrogenism in polycystic ovary syndro...

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Detalhes bibliográficos
Publicado no:J Endocr Soc
Main Authors: Levine, Jon E, Greinwald, Emily P, Felton, Jesi A, Flowers, Matthew T, Willging, Molly M, Shapiro, Robert A, Keen, Kim L, Terasawa, Ei, Uhlrich, Daniel J, Abbott, David Howard
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Reproductive Endocrinology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7207541/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.1320
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